Largest
Our Site Network is embedded in community care
Accelering discovery. Advancing access.
We bring GI & Hepatology research directly into the communities where care happens, connecting sponsors’ scientific ambition with empowered, high-performing research sites. Together, we accelerate time to market for life-changing therapies while expanding access for the patients who need them most.
Powering a network that delivers
We help investigators and sponsors run clinical trials more efficiently,
accelerating enrollment, reducing operational burden, and
delivering reliable results at scale.
accelerating enrollment, reducing operational burden, and
delivering reliable results at scale.
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Sites
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Providers
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Patient reach
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Current studies
Iterative Health randomizes 1 IBD patient every day.
Hear more from our leaders
Learn more about our innovative approach to GI & Hepatology clinical research from our Executives who oversee the teams responsible for sponsor partnerships, site operations, and technology development
Empowering sites to
accelerate trial success
Solving today’s clinical research barriers with a unified, performance-driven site network.
Traditional Model
Challenges across clinical research continue to intensify, slowing the development of new, life‑changing therapies. For healthcare providers, research operations can be complex, resource-intensive, and deliver uncertain return on investment. For life science sponsors, clinical trials frequently face delays, variability, and escalating costs.
New Model
Iterative Health has built a high-performing, global site network specializing in GI and Hepatology—empowering the long‑term success of research sites while connecting sponsors with expert research teams, engaged patient populations, and accelerated pathways to trial success.
Iterative Health Site Network:
Where sites succeed and
research drives innovation forward
By placing sites at the center, we power a global performance-driven network with exceptional patient reach trusted by both Sponsors/CROs and Providers to accelerate life-changing GI and Hepatology therapies to market.
Strategic Partners
We’re proud to partner with leading gastroenterology networks such as GI Alliance and One GI to accelerate the future of clinical research. Together, we help streamline trial operations, expand access to innovative studies, and deliver new treatments to patients faster.
Industry-leading speed and enrollment
Provider partnerships that empower elite research sites
Empowering research sites with the infrastructure, intelligence, and sponsor connections they need to deliver trial excellence and build lasting success
“By combining GIA’s clinical depth with Iterative Health’s innovative infrastructure, we are enabling more physicians and their patients to participate in cutting-edge clinical trials without leaving their communities.”
Casey Chapman
Chief Medical Officer, GI Alliance
Partnering to Accelerate Breakthrough Therapies
By connecting Sponsors/CROs to a high-performing community site network that delivers industry-defying speed and enrollments, we streamline trial execution and accelerate access to life-changing GI & Hepatology therapies.
Explore sponsor partnerships
Accessible research, life-changing results
Clinical trials are more than research—they’re treatment options embedded into community care. In this spotlight, hear from Bruce, a patient with IBD, and our strategic partner, GI Alliance, to see how access to trials offer hope, exceptional patient care, and real-world impact.
Resources and insights in clinical research
Learn from experts, case studies, and best practices that are driving faster, more efficient,
and patient-focused clinical trials in GI, hepatology, and beyond
and patient-focused clinical trials in GI, hepatology, and beyond
A Closer Look at Dr. DuVall’s Clinical Leader Article on Accelerating Clinical Trials
Dr. DuVall outlines how specialized, community-based research sites reduce study activation time, expand patient access, and improve trial execution by embedding research directly into everyday care settings, demonstrating why integrated clinics are critical to delivering faster, higher-quality clinical research in today’s increasingly complex trial landscape.
Learn More
Building Sustainable Clinical Research Sites, Why the Future of Clinical Trials Depends on It: Interview with Dana Feuchtbaum
Dana discusses why sustainable clinical research sites are essential to the future of trials, highlighting staffing challenges, operational strain, and how strategic investment in people, processes, and partnerships can strengthen sites and accelerate patient access to life-changing therapies
Learn More
Case Study: How Gastro One Accelerated a Complex Phase 1b-A GI Trial with Iterative Health
This case study shows how Gastro One, with Iterative Health’s support, accelerated a complex Phase 1b-A GI trial by streamlining operations, improving patient retention, and increasing randomizations. Targeted, high-touch support, from proactive chart reviews to regulatory guidance, reduced team burden and delivered faster enrollment and measurable trial efficiency.
Learn More
Driving Operational Excellence in Ambulatory Surgery Centers: How Iterative Health Accelerates Clinical Trial Success
Iterative Health helps Ambulatory Surgery Centers accelerate clinical trials by streamlining operations, improving recruitment, and ensuring compliance. With AI tools and hands-on support, ASCs activate sites faster, retain patients, and meet milestones efficiently, enabling quicker delivery of novel therapies without overburdening teams.
Learn More
Iterative U: Advancing Clinical Research Through On-Demand Learning
Iterative U provides on-demand, role-specific training for clinical research teams, empowering site staff to sharpen skills, optimize operations, and accelerate professional growth. With specialized GI content, practical workflows, and CE-eligible courses, it equips PIs, CRCs, and site leaders to deliver higher-quality trials while building knowledge and confidence across the research network.
Learn More
How AI is Transforming Clinical Trials, and Why Gastroenterology Stands to Benefit Most
AI is transforming clinical trials by standardizing complex procedures, improving patient recruitment, and accelerating drug development. In gastroenterology, Iterative Health is applying AI to IBD trials, generating consistent disease scores, speeding eligibility assessments, and enabling more efficient, patient-centered research.
Learn More
Connect with us to
advance clinical research
Whether you’re a research site, sponsor, healthcare partner, or exploring career opportunities, we’re here to answer your questions, share resources, and explore how we can work together to accelerate clinical trials and improve patient outcomes. Reach out to learn more about our solutions, partnerships, and career opportunities.
Get in touch
“By improving research with more reliable and standardized assessments, we can accelerate the development of new therapies and generate better data on their efficacy, ultimately enabling providers to make more informed treatment decisions and improve patient care.”
David Rubin, MD
Director of the IBD Center
University of Chicago Medicine
Powering research, accelerating outcomes
We bring GI & Hepatology research directly into the communities where care happens, connecting sponsors’ scientific ambition with empowered, high-performing research sites. Together, we accelerate time to market for life-changing therapies while expanding access for the patients who need them most.
Accelerating novel therapies to market
through collaboration and innovation
Who We Are
At Iterative Health, we believe the future of clinical research depends on thriving, performance-driven sites. Unlike traditional CROs or SMOs, we focus on the success of our sites, empowering their prosperity and trial performance to bridge sponsors’ scientific ambitions. With a growing global site network, Iterative Health brings research directly into the communities where care happens, expanding access and advancing discovery.
Iterative Health Site Network:
Where elite sites drive innovation forward
By placing sites at the center, we power a global performance-driven network
with exceptional patient reach trusted by both Sponsors/CROs and Providers
to accelerate life-changing GI and Hepatology therapies to market.
with exceptional patient reach trusted by both Sponsors/CROs and Providers
to accelerate life-changing GI and Hepatology therapies to market.
Strategic Partners
We’re proud to partner with two leading provider networks, GI Alliance and One GI, to expand access to clinical trials across community-based practices and accelerate the advancement of new therapies for patients.
Powering a network that delivers
We help investigators and sponsors run clinical trials more efficiently,
accelerating enrollment, reducing operational burden, and
delivering reliable results at scale.
accelerating enrollment, reducing operational burden, and
delivering reliable results at scale.
0+
Research
sites
sites
0M
Patient
reach
reach
0+
Current
studies
studies
0X
Trial speed compared
to industry benchmarks
to industry benchmarks
Accessible research, life-changing results
Clinical trials are more than research—they’re treatment options embedded into community care. In this spotlight, hear from Bruce, a patient with IBD, and our strategic partner, GI Alliance, to see how access to trials offer hope, exceptional patient care, and real-world impact.
Empowering sites and sponsorsto accelerate discovery
Partner with Iterative Health to streamline clinical trials, expand
patient access, and leverage AI-powered tools that help sites and
sponsors move research forward efficiently and effectively.
Providers
Grow your research ancillary with access to top-tier studies, support for operational excellence, and innovative AI technology to supercharge patient enrollments
Explore Site NetworkSponsors & CROs
Accelerate trials with the high-performing site network delivering confident site selection, unparalleled activation timelines, and industry-leading patient enrollments
Explore partnershipsJoin our team
Interested in joining our mission to accelerate life-changing therapies to market?
Explore careersResources and insights in clinical research
Learn from experts, case studies, and best practices that are driving faster, more efficient,
and patient-focused clinical trials in GI, hepatology, and beyond
and patient-focused clinical trials in GI, hepatology, and beyond
A Closer Look at Dr. DuVall’s Clinical Leader Article on Accelerating Clinical Trials
Dr. DuVall outlines how specialized, community-based research sites reduce study activation time, expand patient access, and improve trial execution by embedding research directly into everyday care settings, demonstrating why integrated clinics are critical to delivering faster, higher-quality clinical research in today’s increasingly complex trial landscape.
Learn More
Building Sustainable Clinical Research Sites, Why the Future of Clinical Trials Depends on It: Interview with Dana Feuchtbaum
Dana discusses why sustainable clinical research sites are essential to the future of trials, highlighting staffing challenges, operational strain, and how strategic investment in people, processes, and partnerships can strengthen sites and accelerate patient access to life-changing therapies
Learn More
Case Study: How Gastro One Accelerated a Complex Phase 1b-A GI Trial with Iterative Health
This case study shows how Gastro One, with Iterative Health’s support, accelerated a complex Phase 1b-A GI trial by streamlining operations, improving patient retention, and increasing randomizations. Targeted, high-touch support, from proactive chart reviews to regulatory guidance, reduced team burden and delivered faster enrollment and measurable trial efficiency.
Learn More
Latest news
Business WireSeptember 30, 2025
Iterative Health Appoints Bill Kayser as President and Chief Financial Officer
Business WireAugust 26, 2025
Iterative Health and One GI Announce Strategic Partnership, Advancing Research as a Driver of Care Innovation
Business WireApril 23, 2025
GI Alliance and Iterative Health Partner to Advance GI Clinical Research in the Community
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Hear from our CEO
Hear from Jonathan NG, Founder & CEO, on how Iterative Health remains deeply rooted in gastroenterology while expanding our approach to leverage more than just AI technology to tackle complex challenges in healthcare.
Connect with us to
advance clinical research
Reach out to learn more about our solutions, partnerships, and career opportunities.
Get in touchHear from our PI Leadership
and Scientific Advisors
Executives highlight the support and performance that set Iterative Health apart
G. Aaron DuVall, MDTyler Research InstitutePrincipal Investigator
“Scaling research requires than expertise and physician dedication. collaborative [with Iterative Health] site performance, and sustainability, TRI to maintain focus on delivering clinical outcomes and research.”
Ziad Younes, MDOne GIPrincipal Investigator
“Iterative Health has been a trusted partner to our site for several years, and I’ve seen firsthand the depth of their support and expertise.”
David Rubin, MDUChicagoChief, Gastroenterology
“By improving research with more reliable and standardized assessments, we can accelerate the development of new therapies and generate better data on their efficacy, ultimately enabling providers to make more informed treatment decisions.”
Casey Chapman, MDGI AllianceChief Medical Officer
“By combining GIA’s clinical depth with Iterative Health’s innovative infrastructure, we are enabling more physicians and their patients to participate in cutting-edge clinical trials without leaving their communities.”
Accelerating novel therapies to market
through collaboration and innovation
Who We Are
At Iterative Health, we believe the future of clinical research depends on thriving, performance-driven sites. Unlike traditional CROs or SMOs, we focus on the success of our sites, empowering their prosperity and trial performance to bridge sponsors’ scientific ambitions. With a growing global site network, Iterative Health brings research directly into the communities where care happens, expanding access and advancing discovery.
Our promise to
sponsors and CROs
We promise sponsors and CROs faster, more confident site selection, industry-leading enrollment volume per site, and reduced operational burden. With clear visibility into performance and progress, we provide a consistent, reliable partnership across every study and program.
Access expert research teams and diverse patient populations
Our 80+ global research sites are embedded directly within GI and hepatology practices, unlocking immediate access to diverse patient populations. With research built into real-world care, patient enrollment starts on day one.
Case study: Rapid Phase III UC & Crohn’s trial execution
Discover how a leading pharmaceutical company partnered with Iterative Health for three Phase III studies. Sites were activated in under 60 days, achieving first-in-world randomizations and setting a new standard for trial execution.
Expertise and execution that
accelerate GI and hepatology trials
From trial design to patient recruitment and site support, our network delivers specialized capabilities, therapeutic expertise, and high-performing sites all in one integrated approach.
Specialized GI & Hepatology Research
Iterative Health is purpose-built for gastrointestinal and hepatology clinical research, combining deep therapeutic expertise with operational excellence to support complex trials across the full study lifecycle. Our integrated site network and enablement model help sponsors move faster without sacrificing quality or control.
Trial Phases Supported
Phase 1b through Phase 4
We support both early- and late-stage development, enabling sponsors to move efficiently from proof-of-concept through post-marketing studies.
Therapeutic Areas
Gastrointestinal
IBD, IBS-C/D/M/U, Eosinophilic Esophagitis (EoE), Celiac Disease, GERD, C. diff, Barrett’s Esophagus, Gastroparesis, Colorectal Cancer (CRC), and more.
Hepatology
MASLD/MASH, PBC, PSC, ALD, MAFLD, Autoimmune Hepatitis (AIH).
Oncology
Colorectal Cancer (CRC) and Hepatocellular Carcinoma (HCC) screening studies.
Obesity & Metabolic Disease
Weight loss studies, GLP-1 and GIP therapies in comorbid conditions, and management of associated gastrointestinal adverse events.
Study Types Supported
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Interventional studies
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Randomized Controlled Trials (RCTs)
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Observational studies and registries
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Diagnostics and medical device studies
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Biospecimen collection studies
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Site Enablement Model
Iterative Health doesn’t monitor or manage sites — we empower high-performing, sustainable research sites. Our partnership model aligns site capabilities with sponsor and CRO needs to accelerate timelines and improve execution.
Operational & Recruitment Excellence
Centralized teams and technology support trial execution from activation through closeout, ensuring compliance, quality, and momentum.
Includes:
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Regulatory and quality expertise for audit readiness and data integrity
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AI-powered patient identification and pre-screening
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Specialized training and development for site staff
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Integrated study maintenance and closeout support
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Dedicated PI and CRC communication and engagement
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Who We Are
At Iterative Health, we believe the future of clinical research depends on thriving, performance-driven sites. Unlike traditional CROs or SMOs, we focus on the success of our sites, empowering their prosperity and trial performance to bridge sponsors’ scientific ambitions. With a growing global site network, Iterative Health brings research directly into the communities where care happens, expanding access and advancing discovery.
PARTNERING WITH ITERATIVE HEALTHLet's Chat
We’re not stopping here.
Our in-house team of AI specialists and direct access to training data fuel rapid and meaningful innovation based on your feedback.5
Explore several ways Iterative Health empowers our provider partners
Solving today’s clinical research barriers with a unified, performance-driven site network.
Partnership Model for Longevity & Impact
Trusted partner to scale a profitable ancillary service supporting research embedded directly into care and offered as an innovative treatment option
- Financial and budgeting services
- Provider incentives structure
Operational Backbone for Trial Excellence
Empowering elite GI & Hepatology clinical research operations with industry-leading trial performance and data integrity, backed by a team of 50+ clinical research professionals
- Finance, budgets, legal, and reporting
- Study start-up & regulatory management
- Patient pre-screening and recruitment support
- Sponsor/CRO direct communication & resolution management
- Research staff training, hiring, management, and development
Access to New Therapies with Premium Study Opportunities
Expanded access to novel therapies through a robust study pipeline across GI & Hepatology
- Dedicated in-house trial partnership team sources and contracts new study opportunities
- Tap into existing relationships with 40+ pharmaceutical, biotechnology, and CROs
- Premium rate cards secured for our site network with industry-leading trial performance
Iterative Health portfolio companies
Empowering community-based providers with centralized support,
expertise, and scale to accelerate trial success
expertise, and scale to accelerate trial success
Impact Research LLC, a subsidiary of Iterative Health, empowers community-based research with centralized operational support, deep sponsor partnerships, embedded staff, and proprietary technology. Our model combines local patient access with world-class infrastructure to deliver exceptional trial performance, enabling providers to focus on exceptional patient care.
One team
Iterative Health and our portfolio companies work together around a shared purpose: accelerating research to improve patient outcomes. The hub enables this mission by providing centralized operations, services, innovation, and corporate functions. Operating as the heart of the model is our patient-facing research organization, Impact Research, which partners closely with providers at research sites.
Hear our story
Dr. Jonathan Ng, founded our company in 2017 with a clear vision: to tackle the gaps in healthcare and ensure patients get the treatments they need, when they need them. From early experiences as a physician witnessing disparities in care, he imagined a future where clinical research could move faster, smarter, and more effectively to accelerate the delivery of innovative therapies that advance care.
Today, we bring that vision to life by partnering with providers and study sponsors/CROs to strengthen the infrastructure of clinical research and bring novel therapies to market faster.
By combining deep industry knowledge, operational excellence, and cutting-edge technology, we’re increasing access to research within the community care setting, and accelerating the advancement of new therapies for patients.
Hear from our PI leadership
We are proud to partner with world-renowned
leaders in clinical research
“By combining GIA’s clinical depth with Iterative Health’s innovative infrastructure, we are enabling more physicians and their patients to participate in cutting-edge clinical trials without leaving their communities.”
Casey Chapman, MD
Chief Medical Officer
GI Alliance
GI Alliance
“Scaling community research requires more than clinical expertise and physician dedication. This collaborative approach [with Iterative Health] emphasizes site performance, growth, and sustainability, allowing TRI to maintain focus on delivering strong clinical outcomes and patient-centered research.”
G. Aaron DuVall, MD
Prinicipal Investigator
Tyler Research Institute
Tyler Research Institute
“Iterative Health has been a trusted partner to our site for several years, and I’ve seen firsthand the depth of their support and expertise.”
Ziad Younes, MD
Prinicipal Investigator
Gastro One | One GI
Gastro One | One GI
Hear from our leaders
We bring together clinicians, research teams, and corporate partners who share one mission: making clinical trials run smoothly and efficiently from start to finish. From helping sites get up and running to keeping sponsors informed every step of the way, our teams work side by side to remove friction, support people, and get therapies into patients’ hands faster. Hear from some of our leaders in the video to learn more about our approach.
Who We Are
At Iterative Health, we believe the future of clinical research depends on thriving, performance-driven sites. Unlike traditional CROs or SMOs, we focus on the success of our sites, empowering their prosperity and trial performance to bridge sponsors’ scientific ambitions. With a growing global site network, Iterative Health brings research directly into the communities where care happens, expanding access and advancing discovery.